Clinical Evidence for The Safe and Effective Use Of Regenerix

Collagen Hydrolysate

1. Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders. Semin Arthritis Rheum. 2000 Oct;30(2):87-99. Read More
2. Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice. (Journal of Nutrition. 1999;129:1891-1895.) Read More
3. Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue. Read More
4. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders:a review of the literature. Read More
5. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Read More
6. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Read More
7. Collagen Hydrolysate Improves Joint Function in Adults with Mild Symptoms of Osteoarthritis of the Knee. Read More
8. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. Read More
9. A new view concerning the effects of collagen hydrolysate intake on skin properties. Read More
10. Differential effect of ECM molecules on re-expression of cartilaginous markers in near quiescent human chondrocytes. Read More

Hyaluronic Acid

1. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. Read More
2. Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. Read More
3. Hyaluronan facilitates transforming growth factor-beta1-mediated fibroblast proliferation. Read More
4. Involvement of hyaluronan in regulation of fibroblast phenotype. Read More
5. Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis. Read More

Chondroitin Sulphate

1. Effect of chondroitin sulfate and hyaluronic acid on gene expression in a three-dimensional culture of chondrocytes. Read More
2. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Read More