Clinical Evidence
Scientific Validation for Our Products
Collagen Hydrolysate
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Collagen hydrolysate is of interest as a therapeutic agent of potential
utility in the treatment of osteoarthritis and osteoporosis. Its high level
of safety makes it attractive as an agent for long-term use in these chronic
disorders. Semin Arthritis Rheum. 2000 Oct;30(2):87-99.
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Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an
Accumulation of Radioactivity in Cartilage of Mice. (Journal of Nutrition.
1999;129:1891-1895.)
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Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage
Tissue.
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Collagen hydrolysate for the treatment of osteoarthritis and other joint
disorders: a review of the literature.
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Stimulation of type II collagen biosynthesis and secretion in bovine
chondrocytes cultured with degraded collagen.
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24-Week study on the use of collagen hydrolysate as a dietary supplement in
athletes with activity-related joint pain.
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Collagen Hydrolysate Improves Joint Function in Adults with Mild Symptoms of
Osteoarthritis of the Knee.
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Collagen hydrolysate intake increases skin collagen expression and
suppresses matrix metalloproteinase 2 activity.
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A new view concerning the effects of collagen hydrolysate intake on skin
properties.
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Differential effect of ECM molecules on re-expression of cartilaginous
markers in near quiescent human chondrocytes.
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Hyaluronic Acid
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Aging fibroblasts resist phenotypic maturation because of
impaired hyaluronan-dependent CD44/epidermal growth factor receptor
signaling.
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Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan
after oral administration in rats and dogs.
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Hyaluronan facilitates transforming growth factor-beta1-mediated fibroblast
proliferation.
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Involvement of hyaluronan in regulation of fibroblast phenotype.
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Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic
acid synthesis using in vitro cultured synovium cells and oral ingestion of
collagen hydrolysates in a guinea pig model of osteoarthritis.
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Chondroitin Sulphate
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Effect of chondroitin sulfate and hyaluronic acid on gene expression in a
three-dimensional culture of chondrocytes.
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Chondroitin sulphate reduces both cartilage volume loss and bone marrow
lesions in knee osteoarthritis patients starting as early as 6 months after
initiation of therapy: a randomised, double-blind, placebo-controlled pilot
study using MRI.
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Boswellia
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Clinical evaluation of Boswellia serrata (Shallaki) resin in the management
of Sandhivata (osteoarthritis).
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Modulation of the immune system by Boswellia serrata extracts and boswellic
acids.
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Turmeric (Curcumin)
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Curcumin: a novel therapeutic for burn pain and wound healing.
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Ginger (Zingiber officinale)
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Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in
the treatment of symptomatic knee osteoarthritis: a randomized,
double-blind, controlled equivalence drug trial.
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Winter Cherry
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Cherry consumption and decreased risk of recurrent gout attacks.
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Cat’s Claw (Uncaria tomentosa)
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Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa
bark.
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Cat’s claw: an Amazonian vine decreases inflammation in osteoarthritis.
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